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This led to the identification of proglucagon and its derivatives, including GLP-1

Amino acid sequence and heterogeneity of gastric inhibitory polypeptide (GIP)

This study unlike some of the previous ones, used a number of sensitivity analyses to examine the robustness of the results

Verification Steps Verification steps include: Requesting Certificate of Analysis showing purity percentage (should be 95% for injections) and net peptide in vial Verifying product is refrigerated and not expired

Interestingly, while Ex4(2-39) retains high affinity and full activity at 10 nM, the replacement of Asp 9 with Glu resulted in the complete loss of efficacy, despite no effect upon affinity (Montrose-Rafizadeh et al ., 1997), suggesting that Asp 9 plays an important role in activity