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[DOI] [PMC free article] [PubMed] [Google Scholar] 75.Kwon H J, Won Y S, Park O et al
And if twice-daily dosing failed to produce the effect that once-daily morning dosing did, the intuition that timing failures can be solved by adding another dose finds no support in the only data available
It can flip the switch on thousands of genes, encouraging older cells to act more like their younger counterparts
doi: 10.1007/s10571-017-0469-1 Summary Keywords sinomenine, cerebral ischemia, drug delivery, neuroinflammation, bonebrainaxis Citation Li X, Zhang X, Wang T, Li H, Li Y, Liu J and Bai Y (2025) Sinomenine in cerebral ischemia: mechanisms, delivery strategies, and the emerging multifunctional biomaterials of the bonebrain axis