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Recent evidence supports the use of lower or alternate day dosing strategies to improve absorption and reduce gastrointestinal side effects, which are a common barrier to adherence

Consider over-the-counter options if needed Occasionally, mild stool softeners, osmotic laxatives, or fiber supplements may help relieve constipation

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The mechanisms include endothelial dysfunction, autonomic neuropathy, reduced nitric oxide bioavailability, and psychological factors related to chronic disease management