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In isolated human islets, somatostatin is released in response to increasing glucose concentrations ( Endogenous somatostatin is regulated by intra-islet paracrine influences ( The emerging picture of healthy glucose-insulin secretion coupling is less an isolated -cell driven action, but more a finely tuned paracrine counterbalance between all islet cell components

Patients with pre-existing mental health conditions should be monitored closely when starting Ozempic, and any new or worsening mood symptoms should be reported to a healthcare professional promptly