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However, the mouse model does not mimic the classic male renal phenotype because only small-fiber neuropathy and hypertrophic cardiomyopathy are the key features of the model 6,34

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For example, poorly digested proteins can be fermented by bacteria in the gut to form amino acid-derived metabolites, such as branched-chain fatty acids (BCFAs) and ammonia, which can have toxic impacts on the intestinal tissue, contributing to leaky gut

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