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However, GCL is upregulated by estradiol, leading to a higher concentration of glutamyl-cysteine (Glut-Cys) in females, thereby driving increased GS flux

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These endotoxins then travel throughout your body, including to your brain, where they activate microglia and trigger the exact neuroinflammatory cascade we see in Alzheimer's, Parkinson's, and other neurodegenerative diseases

It also stimulates the overexpression of the transient receptor potential melastatin 2 (TRPM2) ion channels, triggering macrophage activation, leading to a systemic immune response

TYPICAL DOSING (GENERAL GUIDANCE) Common clinical dosing ranges include: Oral: 5002,000 mcg daily Injectable: 1,000 mcg weekly to monthly, depending on need Dosing is individualized based on laboratory values and symptoms