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A variety of signaling pathways, such as ERK1/2 [28], JNK1/2 [29], p38MAPK [30], PKC [31], and PI3K [32, 33], and transcription factors, such as c-Jun [29], NF-B [27], JunD [34], and Nrf2 [25], etc., have been found to be involved in the regulation of GCLC and GCLM genes

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