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In contrast, cyanocobalamin, a synthetic form of B12, must be converted into Methylcobalamin or adenosylcobalamin in the body before it can be used

Nicotinamide N-methyltransferase (NNMT) inhibition: A novel strategy for the treatment of metabolic diseases

It's also involved in immune cell function and cellular repair

Effect of two different sublingual dosages of vitamin B12 on cobalamin nutritional status in vegans and vegetarians with a marginal deficiency: A randomized controlled trial

Some chemotherapy drugs or antiretroviral medications (for HIV) that suppress bone marrow might also blunt the effectiveness of B therapy