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AD is the fifth leading cause of death in those 65 or older [56]

We are also interested in the correlated changes across all three modalities, as the comparison between brain metabolism and function has important implications for medical imaging biomarkers, both when metabolism and function are correlated [27] and also when they diverge [28]

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However, despite the Food and Drug Administration recently raising concerns about the side effects of unapproved GLP-1s for weight loss, one-third of GLP-1 users have switched from brand-name to compounded or custom-mixed drugs

Third, oral options like orforglipron trade some efficacy for dramatically improved convenience