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On the other hand, blackish purple pigmented rice with a giant embryo significantly decreased blood glucose and plasma insulin levels, adipokine concentrations, and hepatic glucose-regulating enzyme activities in ovariectomized rats [62]

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At the level of precursor lesions such as nevi, the initial mutagenic events triggering the neoplastic transformation are represented by several mutations which lead to the activation of the MAPK pathway (such as BRAF V600E), while at an intermediate stage of tumour progression, NRAS and additional driver mutations are seen

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