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Polycyclic aromatic hydrocarbons (PAHs) found in cigarette smoke, for example, have been shown to decrease the activity of P450 enzymes, leading to a decrease in SAMe production and impaired DNA methylation
The conclusion from the authors of the study was that people need to take the medication indefinitely if they want to maintain their weight loss and cardiometabolic benefits
However, this effect was not observed in rats treated with estradiol alone
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