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The clinical significance threshold sits around 5-10% weight loss for meaningful health improvements

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In parallel, Eli Lillys Foundayo (orflorglipron), a small molecule oral GLP-1, reached the US market in April 2026, opening a new competitive front against Novo Nordisks oral Wegovy

This means, Acetyl Hexapeptide-8 does have some ability to smooth wrinkles (but not as well as Botox - sorry, if we sound like a broken record)

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