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J Neurochem (2012) 122(1):2219.10.1111/j.1471-4159.2012.07763.x 24 BorkumJM

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The formation of ice crystals can stress and fracture the delicate amino acid chains, much like shaking does

Additionally, the proportion of patients achieving full ON by 9:00 AM increased from 36.8% at Day one to 81.3% at Day 28, demonstrating improved morning symptom control

Additionally, DSIP attenuates ACTH and corticosterone release in response to stress, indicating an effect on the hypothalamic-pituitary-adrenal axis [8]