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Somatic mutations in the Thyrotropin receptor gene cause hyperfunctioning thyroid adenomas

Pregnancy planning also affects durationmedication-specific washout periods apply (approximately 2 months for semaglutide, 1 month for tirzepatide/dulaglutide, and immediate discontinuation for liraglutide when pregnancy is recognized)

If this signal holds across TRIUMPH-1, TRIUMPH-2, and TRIUMPH-3, retatrutide could end up with a lipid profile that no other compound in the class shares

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Biopsy-proven NASH : Patients with histologically confirmed NASH, particularly those with significant inflammation or early fibrosis (F1-F2), may be considered for off-label GLP-1 therapy, especially if they have failed lifestyle modification or have contraindications to other therapies like vitamin E or pioglitazone