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(87) utilized a two-by-two factorial design over 4.6 years with 25,871 middle-aged or older adults, including 1,032 with a history of probable migraine, and found that neither vitamin D nor marine omega-3 PUFAs supplementation affected migraine frequency or severity compared to a placebo

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Other subclassesfor example, the flavan-3-ols (catechins found in green tea) and isoflavones (soy-derived phytoestrogens)also exhibit neuroprotective activities in experimental models of PD (28)

This hypothesis is supported by a study demonstrating compositional gut microbiome differences between premenopausal women ( n = 44) and men ( n = 42) that were considerably less pronounced between postmenopausal women ( n = 45) and men ( n = 48) (66)

Clinical Update 2/09/2024 Coffee & Blood Pressure Does drinking regular coffee increase blood pressure in people taking blood pressure-lowering medication