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22 Interaction between genes, termed epistasis, is a phenomenon increasingly highlighted in the area of genetic epidemiology

The average total body weight reduction with tirzepatide was 21.3%

Genitourinary Common (1% to 10%): Urinary tract infection, urolithiasis Postmarketing reports : Urolithiasis Hepatic Common (1% to 10%): Cholelithiasis, cholecystitis Uncommon (0.1% to 1%): Increased bilirubin Postmarketing reports : Cholecystitis, cholelithiasis requiring cholecystectomy Hypersensitivity Uncommon (0.1% to 1%): Hypersensitivity Rare (0.01% to 0.1%): Anaphylactic reaction Frequency not reported : Allergic reactions Postmarketing reports : Hypersensitivity, anaphylaxis Hypersensitivity included related adverse events such as rash and urticaria

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