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Metformin is generally weight-neutral or causes slight weight loss

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Consuming undenatured type-II collagen may help the immune system develop oral tolerance, teaching the T cells to ignore collagen encountered in joints

Results may take longer with microdosing than standard dosing, meaning patience and consistent monitoring are key to making it work

Patients using once-weekly semaglutide are advised to make lifestyle changes, including a reduced-calorie diet and increased physical activity, to improve the efficacy of the drug for optimal weight loss