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For example, an XGBoost model developed by Thapa et al
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In the STEP trials, semaglutide was administered as part of a comprehensive lifestyle intervention that included a reduced-calorie diet (approximately 500 kcal/day deficit based on baseline energy requirements) and a minimum of 150 min of physical activity per week [38,39,40,41,42,43,44,45,46, 78, 97]
Notwithstanding the reported differences, this cellular distribution characteristic may lend itself to alternative strategies to interfere with AR action, also in CRPC cells
The risk of hypoglycaemia would be more relevant if either agent were used alongside insulin or a sulfonylurea, or in the context of severe caloric restriction
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