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Inflammatory microglia have several deleterious effects, including shifting astrocytes from a protective to an inflammatory phenotype via the secretion of extracellular vesicles and cytokines, such as IL1a, TNF, and C1q

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J Neurosci 23:59285935 Aureli T, Di Cocco ME, Puccetti C, Ricciolini R, Scalibastri M, Miccheli A, Manetti C, Conti F (1998) Acetyl-L-carnitine modulates glucose metabolism and stimulates glycogen synthesis in rat brain