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Both belong to the GHRH-analog class molecules that act on the GHRH receptor, the same target as the native hypothalamic hormone

What MTHFR Does and What Goes Wrong When It Doesn't MTHFR (methylenetetrahydrofolate reductase) catalyzes the irreversible conversion of 5,10-methylenetetrahydrofolate (5,10-MTHF) to 5-methyltetrahydrofolate (5-MTHF) the predominant circulating form of folate and the methyl donor required by methionine synthase (MTR) to convert homocysteine back to methionine