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doi: 10.1073/pnas.71.8.2969

Looking ahead, the influence of US policy and Most Favoured Nation (international reference) pricing will remain a central trend that shaped obesity care in 2025 and will continue to do so into 2026 and beyond

Therefore, it is urgently necessary to clarify the core influencing factors that regulate the direction of its effects

It's actually working exactly as designed, but it's responding to the wrong signal

Interestingly, a subgroup analysis of the Thiazolidinediones Or Sulfonylureas Cardiovascular Accidents Intervention Trial (TOSCA.IT) suggested that even low doses of PIO can significantly improve liver steatosis and inflammation in patients with T2D independently of its blood glucose lowering effect [54]