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Once activated, caspase-3 initiates the cleavage of a downstream substrate, such as nuclear poly (ADP-ribose) polymerase (PARP), which facilitates cellular disassembly and serves as a biomarker of cell apoptosis

Holderbaum 2018 systematic review Chakravartty 2019 RCT VLCD safety (short-term, supervised): Classic and consensus statements on efficacy/safety when medically monitored

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Further evidence of the innate effect on neurons goes with the mentioned BPC 157 application, which increased both the survival rate of cultured enteric neurons and the proliferation of cultured enteric glial cells (EGCs) [119]

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