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If high exercise intensity is sustained for prolonged periods, phosphocreatine levels will deplete, lactate production will rise, and muscle fatigue will ensue, ultimately impairing the ability to maintain intense exercise

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The reaction appears to be rare and, in most cases, resolves on its own within a few weeks, according to a 2025 case report in Cureus

Some time, elevated ET cause premature leaf and fruit drop in the plants attacked by biotrophs (Etesami et al., 2020)

One study that looked at the relationship between obesity in men and testosterone deficiency shows that testosterone therapy produces sustained weight loss without recidivism (reverting to previous weight)