Serum and plasma samples were obtained by centrifugation at 3500 rpm for 15 min, transferred into labeled microtubes, and stored at temperatures below 20 C until analysis
The checkerboard dilution method was used to determine the MIC of drug combinations [25], and the fractional inhibitory concentration (FIC) index was applied to evaluate combination effects
Generally, alcohol can enhance the sedative effects of Metoprolol (dizziness, drowsiness), so limiting or avoiding alcohol is often advised
Wright JM
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