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If leg cramps began or worsened after a dose increase, discuss with your provider whether temporarily maintaining the current dose longer before further escalation might allow your body more time to adjust

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The hypothesis is that by combining these two agents, one addresses the systemic hormonal signals that govern eating behavior and macroscopic energy balance, while the other fine- tunes the cellular machinery responsible for metabolic efficiency

This can lead to an immediate sense of fullness after even small snacks