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Patients with a history of alcohol use disorder, liver disease, or frequent hypoglycemia should discuss any alcohol use with their prescribing clinician before or immediately after starting GLP-1 therapy

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A 2024 retrospective chart review found that 67% of IBS-D (diarrhea-predominant) patients using GLP-1 medications reported moderate to significant symptom improvement within 812 weeks of starting treatment

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The tissues were lysed in sonication buffer (20 mM HEPES pH7.5