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Detox pathways can slow down without adequate B12, leading to increased fatigue, hormonal imbalance and sluggish digestion

This reflects the biological chronicity of obesity: the hypothalamic set-point for body weight, appetite hormone profiles (including leptin and ghrelin), and resting metabolic rate tend to revert toward pre-treatment baselines once pharmacological GLP-1 stimulation is removed

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Missing multiple consecutive days should prompt a discussion with your provider about whether to restart the cycle