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Supporting the genetic basis of these associations, a recent hospital-based case-control study in Korean women identified variants in the melatonin receptor gene MTNR1A that were linked to BC risk, with certain polymorphisms interacting with NSW to further elevate susceptibility, highlighting a gene-environment interplay in circadian disruption-mediated breast carcinogenesis 195
f , Volcano plot showing relative fold change (log 2 ) in IP protein abundance versus log 10 (adjusted P value) from HEK293T cells expressing ER-tag compared to those expressing control-tag (n = 3, P-value adjusted for 1% permutation-based FDR correction)
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The role of steroid hormones in prostate carcinogenesis
