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Furthermore, the trajectory of the weight loss curves suggested that at 48 weeks the plateau of weight was not yet reached and all the participants in the 8 and 12 mg had a weight reduction of 5% or more, which is currently the minimum threshold for efficacy [64]

doi: 10.1016/j.jid.2018.04.029 265 YangYLZhouCChenQShenSZLiJDWangXLet al

[PubMed: 984142] 141

When to Pause or Adjust the Protocol Communicate with your physician if: GI side effects from your GLP-1 medication aren't improving after three to four weeks You experience persistent water retention or joint discomfort from Ipamorelin Your lab results show IGF-1 above the reference range You're losing weight too rapidly (more than 3 to 4 pounds per week consistently) You develop any new or concerning symptoms Frequently Asked Questions Can I start both peptides at the same time to save time