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Therefore, GCN2 expression in tumor cells, CD4 + T cells, and myeloid cells is associated with a protumor effect, promoting tumor cells survival and restricting antitumor immunity

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doi: 10.1016/j.ccell.2018.07.014

Current Evidence Level Stating the evidence tier precisely, without softening: Weighing the positive and negative studies The positive human evidence is real but structurally weak, and the weakness is specific: nearly all of it comes from a single investigator group