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DRUG IT must be activated to be a good leaving group Hydroxyl group is a bad leaving group Examples Estradiol Examples Morphine is extensively metabolized into glucuronide conjugate Example of C-glucuronidation Nucleophilic attack Because this H-atom is acidic Sulfation (sulfate conjugation) Occurs primarily for phenols and occasionally for alcohols, arylamines, and N-hydroxy compounds catalyzed by sulfotransferase enzyme

Figure 12 shows no substantial reduction in the activity of the murine tyrosinase by C3G while higher inhibition for the murine tyrosinase enzyme was noted for EC and CH against ARB inhibitor and control (no treatment)

McAleer JP, Kolls JK