[Internet] [DOI] [PMC free article] [PubMed] [Google Scholar] Ng M, Gakidou E, Lo J, Abate YH, Abbafati C, Abbas N, Abbasian M
412 Notably, GLP-1RAs, including exendin-4, have been shown to attenuate microglial activation, resulting in a reduction in the expression of proinflammatory cytokines such as TNF- and IL-1
For type 2 diabetes , NICE recommends GLP-1 receptor agonists as second- or third-line therapy when metformin and other oral agents have not achieved adequate glycaemic control, or as an alternative to insulin in certain circumstances
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A mean reduction in body weight of 7% in participants following a low-energy diet resulted in significantly more patients responding (according to reduction in PASI score) to low-dose ciclosporin [17]