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Unfortunately, VEGF can also be detrimental because its overexpression can cause inflammation in the nervous system, which in turn can lead to BBB leakage, promote the production of pro-inflammatory cytokines and the occurrence of neurodegeneration (Claire and Larrive 2017

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Methods Animal studies All experiments were performed under the UK Home Office project licence PE50F6065 in accordance with the UK Animals (Scientific Procedures) Act, 1986, and approved by the University of Cambridge Animal Welfare and Ethical Review Body

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