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Methods: Patients treated with rtPA in a public tertiary center in San Jos Costa Rica, from February 2012 to December 2023 were retrospectively included in the analysis

10.1093/femsle/fnad113

To test whether E27 accounts for STAT2 downregulation, an RCMVE mutant lacking E27 was constructed by CRISPR/Cas9mediated mutagenesis resulting in an E27deficient RCMVE (E27)

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