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Flowchart outlines process for diagnosing PA and Antibody Negative PA in UK BMJ B12 article bmj.com/content/349/bmj.g5226 Emphasises need to treat patients who are symptomatic even if their B12 level is within range

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They activate different intracellular signaling cascades (cAMP/PKA pathway in fat cells vs incretin signaling in gut and brain)

ICH Q2(R2), Validation of Analytical Procedures