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Notably, the SOS study showed that in people with T2D, achieving and maintaining 15% WL over 15 years was associated with reductions in both micro- and macrovascular complications following BS [54]

68,69,70,71,72,73,74 Genetic factors have also been suggested

Retrograde delivery of S is due to a Lys-x-His-x-x CT sequence in its cytosolic tail, which partially mimics the coatomer-binding dibasic motif 11,12

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