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The Filippin group demonstrated progressive weight loss beginning at week 2 following arthritis induction in the CIA model ( plantaris , and GA with less weight than healthy mice, with high systemic IL-6 and TNF- levels

This patient with documented PD-L1 expression was treated with the checkpoint inhibitors pembrolizumab, ipilimumab, and nivolumab with pain improvement, but no objective response in disease progression

Gastroenterology 120:A683