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En personas con diabetes tipo 2, la respuesta incretina suele estar disminuida, lo que implica tanto una reduccin en la secrecin como en la accin del GLP-1, contribuyendo al descontrol glucmico

A separate study of 480,000 GLP-1 users by researchers in Mexico points to a similar pattern: 13.6 per cent developed a significant vitamin D deficiency within a year of starting the drugs, while around 60 per cent werent getting enough iron or calcium from their diets

However, as with all medications, these treatments are not substitutes for lifestyle changes, and their long-term success often depends on integrating them with a structured plan involving diet, movement, and behavioural support