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Canalis E, Centrella M, Burch W, McCarthy TL

With further optimization to the formulation and dosing of antioxidant gel-forming eye drops, there is potential for a topical therapy to protect photoreceptor function and survival for the treatment of RP

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GSH Metabolism, Biosynthesis & Health Implications (PubMed, 2004) Cysteine Availability as the Rate-Limiting Factor in GSH Synthesis A widely cited review of glutathione metabolism published on PubMed documented the two-step cytosolic biosynthesis pathway in detail, confirming that GSH synthesis is regulated primarily by gamma-glutamylcysteine synthetase activity, cysteine availability, and GSH feedback inhibition

Inhibiting lipid peroxidation and ferroptosis by antioxidants might provide a novel therapy for OA