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Cardiovascular Risk Factors Beyond blood sugar and weight, orforglipron also showed improvements in several cardiovascular risk markers, including total cholesterol, non-HDL cholesterol, triglycerides and systolic blood pressure

But the rationale is sound: GLP-1 receptors exist on a continuum of activation, and partial activation may produce partial benefits with fewer side effects

A: Physical activity, a low-calorie diet, and hydration boost the weight-loss benefits

They can recommend the safest way to do so, which may include a gradual taper over the course of several weeks to minimize hunger spikes and weight regain