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NICE guidance (NG145) recommends offering levothyroxine for overt hypothyroidism (elevated TSH with low free T4)

Titration : Starting on a low dose, progressively increased, to help your body adjust

doi: 10.3390/molecules22030388

7,8 This finding led to three trials in adults with obesity or overweight without diabetes, which confirmed a dose-dependent weight reduction with liraglutide

"When I treat patients in the diabetes clinic, I see a huge variation in response to these GLP-1-based medications and it is difficult to predict this response clinically," says endocrinologist Mahesh Umapathysivam, from Adelaide University in Australia