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GIP is a sister hormone and analogs have shown neuroprotective effects in preclinical models of PD

Nausea is typically most pronounced during the first few weeks of treatment and during dose increases, with most cases being mild to moderate and diminishing over time as the body adapts to the medication

[DOI] [PMC free article] [PubMed] [Google Scholar] 56.Nexe-Larsen C.C., Srensen P.H., Hausner H., Agersnap M., Baekdal M., Brnden A., Gustafsson L.N., Sonne D.P., Vedtofte L., Vilsbll T., et al

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Understanding this distinction helps explain why many commonly used pain medications particularly corticosteroids can provide short-term symptom relief while quietly worsening long-term metabolic, immune, and tissue health