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They require: Kidney function monitoring (GLP-1s require dose adjustment in renal impairment) Thyroid screening (personal or family history of medullary thyroid carcinoma is an absolute contraindication) HbA1c and blood glucose tracking Pancreatic enzyme awareness in at-risk patients Lipid panel follow-up Blood pressure monitoring The American Diabetes Association Standards of Medical Care recommend HbA1c, renal function, and lipid panels as part of baseline metabolic assessment before initiating GLP-1 therapy.[4] The American Association of Clinical Endocrinology similarly recommends comprehensive metabolic evaluation including thyroid assessment prior to weight loss pharmacotherapy.[5] Many telehealth platforms do not meet these standards

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It has not been approved as a standalone drug by the FDA, placing it in the same regulatory category as most research peptides available through compounding under prescriber supervision