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You should seek medical advice promptly if you experience: Severe or persistent abdominal pain , especially if accompanied by fever or vomiting seek urgent medical attention if severe and persistent Signs of gastrointestinal bleeding black, tarry stools, blood in vomit, or vomit resembling coffee grounds call 999 or go to A&E immediately Severe, persistent nausea or vomiting that prevents adequate fluid or food intake, risking dehydration and potential kidney problems Symptoms of pancreatitis severe upper abdominal pain radiating to the back stop taking Ozempic and seek urgent medical attention Jaundice (yellowing of skin or eyes) or pale stools, which may indicate gallbladder or liver problems Unexplained, rapid weight loss or inability to maintain adequate nutrition Patients should contact their GP or diabetes specialist nurse if gastrointestinal side effects persist beyond the first few weeks of treatment or significantly impact quality of life