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They signal fibroblasts to make more collagen and elastin

Increase in intracellular cholesterol content and storage depends on activation of PI3K-Akt-mediated stimulation of SREBP pathway [31], which induces de novo synthesis of sterol or preserves the LDLR-mediated cellular uptake [32, 33]

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For example, peptides like MK-677 Ibutamoren stimulate growth hormone secretion, which supports muscle growth, enhances fat breakdown, and improves overall metabolic function

Importantly, these neurological complications can occur even when anaemia is absent or has been corrected with folic acid supplementation, which is why distinguishing between the two deficiencies is clinically vital