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The relationship between alcohol and health is not linear, and while low-level drinking has historically been associated with some cardiovascular benefits, more recent research applying Mendelian randomisation methods suggests that even moderate drinking carries some increased risk

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For example, water-soluble vitamins often act in the cytosol of cells (the fluid inside of cells) or in extracellular fluids such as blood, while fat-soluble vitamins play roles such as protecting cell membranes from free radical damage or acting within the cells nucleus to influence gene expression