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In addition to increasing inflammation, environmental toxins have been shown to cause cancer, heart disease, obesity and diseases of the nervous system, just to name a few

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However, recent evidence from animal models, ex-vivo studies on cells isolated from deficient subjects, in vitro studies where deficiency was induced by gene silencing, and large human cohorts indicate that G6PD can lead to adverse physiological effects in response to increased oxidative stress [14] acting as a cardiovascular risk factor [1518]