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When estrogen declines, so does one of your bodys natural shields against oxidative stress

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The contribution of corticosterone to the suppressed T-cell hepatitis in ethanol-fed Aldh2 -/- mice was demonstrated by the fact that blockade of corticosterone with the steroid antagonist RU486 restored T-cell hepatitis in these mice

So putting collagen-fragment-identical peptides on the skin might trick it into thinking that new collagen is needed

On top of that, ERK1 and ERK2 proteins were also decreased in a concentration-dependent manner with curcumin (Malik et al., 2009)