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No published clinical or veterinary data validate oral dosing in any species
2018, doi: 10.3390/ijms19123862
The implications of centrally produced, neuromodulatory GLP-1 in the context of GLP-1RAs are uncertain, as the degree to which signals from pre-proglucagon neurons/endogenous GLP-1 system and GLP-1RA activity converge on shared downstream targets is unclear 6 and may in fact occur independently 7
Metformin may also cause gastrointestinal side effects including abdominal distension, diarrhea, cramps, nausea, and vomiting (Dixon et al., 2023)
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