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Em caso de gravidez ou amamentao a toma deve ser feita sob indicao mdica

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Sustained glial activation drives neuroinflammation in a vicious cycle via reactive oxygen species (ROS), cytokines, and chemokines (Thakur et al., 2023)

The pyruvate dehydrogenase complex consists of 3 enzymes that convert pyruvate (a key intermediate in several metabolic pathways) into acetyl-CoAvitamins B1 (thiamin) and B3 (niacin) are needed for this complex

Most preclinical studies utilize supraphysiologic doses, alternate routes of administration and short follow-up windows that do not mimic human reproductive timelines